Aqueous Extract of Sparganii Rhizoma and Curcumae Rhizoma Induces Apoptosis and Inhibits Migration in Human Oral Squamous Cell Carcinoma

Sparganii Rhizoma and Curcumae (SRCR) are natural herbs used in traditional Chinese medicine to treat tumors activate blood circulation. Previous studies have shown that SRCR possesses notable antitumor activity; however, the mechanism underlying anticancer activity human oral squamous cell carcinoma (OSCC) has yet be fully elucidated. The risk factors of OSCC include smoking, alcohol consumption, poor hygiene, papillomavirus infection. is highly metastatic responds poorly chemotherapy; thus, alternative treatment options imperative. In this study, we found induced death cells but not normal (HGF-1 cells). also induce production reactive oxygen species cells, sequentially promoting calcium release stress endoplasmic reticulum, which resulted mitochondrial dysfunction subsequent apoptosis. Furthermore, inhibit migration by reducing matrix metalloproteinase-12 -13. Our findings demonstrate exerts activities inducing apoptosis suppressing migration.